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Active Projects
Multidisciplinary registry research of transgender individuals
Principal Investigator: Natalie Cusano, MD
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Sponsor: New York State Empire Clinical Research Program (ECRIP); Lorraine Allen Endowment
Description: The project will focus on managing cardiovascular and bone density health in a cohort of transgender individuals as they age through registry maintenance.
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Multidisciplinary research study to examine cardiovascular and bone density health in transgender individuals
Principal Investigator: Natalie Cusano, MD
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Sponsor: New York State Empire Clinical Research Program (ECRIP)
Description: The fund will be used to study cardiovascular and bone density health in a transgender population. The project will focus on managing cardiovascular and bone density health in a cohort of transgender individuals as they age through routine blood tests, cardiovascular procedures and DXA scans.
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Thyroid Neoplasia in LatinX patients
Principal Investigator: Jose Sanchez Escobar, MD
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Sponsor: New York State Empire Clinical Research Program (ECRIP)
Description: The funds will be used to investigate the clinical impact of diagnosing a thyroid neoplasm in LatinXpatients; and examine novel, nonsurgical strategies to reduce the impact of over diagnosing thyroid neoplasms in this under-represented minority population through a registry & clinical procedures.
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Effects of synthetic mono-carbonyl curcumin analogues on diabetes via modulation of oxidative stress and inflammation
Principal Investigator: Dimitar Avtanski, PhD
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Sponsor: Barbara and Donald Zucker Grant Program for Lenox Hill Hospital/MEETH
Description: Curcumin, a natural polyphenolic compound found in the rhizome of Curcuma longa (turmeric), is reported to have numerous biological activities against diabetes and diseases of the cardiovascular, pulmonary and neurological systems. It has been widely investigated for its anti-oxidative and anti-inflammatory properties. To overcome limitations of curcumin related to its poor in vivo bioavailability, various curcumin analogues were synthesized and tested. The purpose of this project is to investigate the effects of two synthetic mono-carbonyl analogues of curcumin [(2E,6E)-2,6-bis[(2-trifluoromethyl)benzylidene] cyclohexanone (C66) and (2E,6E)-2,6-bis(2- bromobenzylidene) cyclohexanone) (B2BrBC)] on oxidative stress and inflammatory markers in experimental animal models of diabetes. In collaboration with the University of Skopje in Macedonia, we explored the effects of two novel mono-carbonyl analogues of curcumin, C66 and B2BrBC, in streptozotocin (STZ)-induced diabetic rat model. The synthesis of these polyphenols and the in vivo experiments were performed in Macedonia, while the molecular analyses were carried out in our research laboratory at Friedman Diabetes Institute, Lenox Hill Hospital, Northwell Health. Initial results from our study demonstrated that both compounds significantly reduced the effect of STZ on oxidative stress parameters (MDA, AOPP, SOD, CAT, and GPx). Our future studies aim to investigate the effect of these curcumin analogues on diabetes as we are planning to perform additional in vitro experiments to understand the molecular mechanisms of their action. The knowledge obtained from this project is expected to shed light on the molecular mechanisms of action of the C66 and B2BrBC and may lead to the development of novel therapeutic strategies for diabetes.
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Shire – Paradighm (Physicians Advancing Disease Knowledge in Hypoparathyroidism): A Registry for Subjects with Chronic Hypoparathyroidism
Principal Investigator: Natalie Cusano, MD
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Sponsor: Shire Human Genetic Therapies, Inc. (Shire)
Description: The objectives of this registry are to characterize and describe the clinical course of chronic hypoparathyroidism under conditions of routine clinical practice. This includes, but is not limited to, treatments, symptoms, health-related quality of life (HRQoL), clinical outcomes, and comorbidity. In addition, to characterize and describe the long-term efficacy and safety profile of rhPTH (1-84) treatment in patients with chronic hypoparathyroidism under conditions of routine clinical practice. This includes, but is not limited to, long-term effects of rhPTH (1-84) on renal, eye, bone, cardiovascular, and other outcomes relevant for patients with hypoparathyroidism.
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Medtronic – IMPACT2: In-Home Study with MiniMed™ 780G Pump Automated Control in Type 2 – Evaluation of the AHCL System in Adults with Insulin-requiring Type 2 Diabetes
Principal Investigator: Leonid Poretsky, MD
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Description: The objective of this study is to assess the safety and effectiveness of the MiniMed 780G system when used by adults with insulin-requiring type 2 diabetes.
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In vitro effects of experimental monocarbonyl analogues of curcumin on breast cancer progression
Investigators: Dimitar Avtanski, PhD; Radoslav Stojchevski, MSc
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Description: Breast cancer is the second leading cancer type and cancer death in women. Currently, metastatic conditions remain incurable as 5-year survival rate for women with metastatic breast cancer is only 28%. 1 Many natural plant compounds used for millennia in culinary and traditional medicine attracted research because of their pleiotropic actions and lack of serious side effects. Curcumin, a polyphenolic compound present in turmeric plant, has been widely studied for its actions in cardiovascular, digestive, and nervous systems as well as its anti-cancer properties. Major drawback for implementing curcumin treatment is related to its poor bioavailability, a problem that can be overcome with the design of analogues with better absorption and metabolism. The aim of this project is to investigate the in vitro effects and the mechanism of action of two experimentally designed analogues of curcumin ((2E,6E)-2,6-bis[(2- trifluoromethyl)benzylidene] cyclohexanone (C22H16F6O) (C66) and (2E,6E)-2,6-bis(2-bromobenzylidene)cyclohexanone (C20H16Br2O) (B2BrBC)) on breast cancer progression. Our initial experiments demonstrated that both of these compounds reduce oxidative stress and inflammation in experimental animals as well as suppress proliferation, migration and invasion while inducing apoptosis in breast cancer cells in vitro. Our further goal is to extend these initial results and to investigate the effect of C66 and B2BrBC on epithelial to mesenchymal transition (EMT) and cancer stemness aiming to establish a mechanism of their action. Results obtained from this project are expected to shed light on the mechanism of breast cancer metastasis and the use of chemically modified synthetic analogues of curcumin as potential supplemental treatment.
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Investigation of the molecular mechanisms by which hypoxia modulates cytokine secretion in breast cancer cells
Principal Investigator: Dimiter Avtanski, PhD
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Sponsor: Barbara and Donald Zucker Grant Program for Lenox Hill Hospital/MEETH
Description: The purpose of this project is to investigate the effect of CoCl2-induced hypoxia on cytokine gene and protein expression, to establish major signaling pathways involved in the hypoxia-induced effect on cytokine production in breast cancer cells, to investigate the effect of HIF-1α inhibition on breast cancer cytokine production, to investigate the association of tumor HIF-1α expression with tumor cytokine levels.
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Transcending the Usual: Transforming Care for Transgender People
Principal Investigator: Dr. Minghao Liu
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Sponsor: Katz Institute for Women’s Health Innovation Grants Program
Description: This project will aim to develop an innovative model for delivery of multidisciplinary care to the transgender community. The project seeks to transform clinical care of transgender patients in New York City and surrounding areas through patient and health affiliate outreach to spread awareness of our multidisciplinary team of providers specializing in transgender care, educating and providing support for transgender patients and educating providers and medical trainees on gender-affirming care. We will publish marketing media to draw transgender patients to our multidisciplinary practice targeted towards transgender health. We will also develop and distribute educational materials for transgender patients. We will develop a curriculum for teaching medical trainees (medical students, residents, fellows) about transgender health. We will organize seminars and workshops for patients led by LGBT advocates and leaders. We will train staff members on interacting with and caring for transgender patients.
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A mixed-methods study to explore the social impact of first bone fracture on women with osteoporosis: Patient and caregiver perspectives
Co-Investigator: Dr. Tara Kim
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Sponsor: Katz Institute for Women’s Health Innovation Grants Program
Description: The major goal of this study is to determine the impact of fracture on social isolation.
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General Electric (GE) – Pilot study of feasibility and safety of multiple-site abdominal ultrasound stimulation on glycemic control, body composition and ultrasound liver QDI in T2DM
Investigators: Dr. Leonid Poretsky; Dr. Tara Kim
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Description: The aim of this project is to explore innovative management options for patients with type 2 diabetes mellitus.
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An annual fellowship program for highly talented investigators working under the mentorship of prominent scientists in diabetes, human nutrition and related topics was founded in 2000 by The Gerald J and Dorothy R Friedman NY Foundation for Medical Research.
*10/19 – U.S. News & World Report ranked us #9 out of 5,000 medical centers nationwide in Adult Diabetes and Endocrinology!