2021
PUBLICATIONS:
Original Peer Reviewed / Peer Review Articles:
Journal of Clinical & Translational Endocrinology, DOI: 10.1016/j.jcte.2021.100262, 2021
NPJ Breast Cancer, 2021, 7(1):1-13
Mendeley Data, 2021, V1, DOI: 10.17632/gr3dg36nzx.1
Interventional Cardiology, 13, S5:120-124, 2021
In “Osteoporosis: A Clinical Casebook” Cusano NE, Ed., Springer, 2021
Metabolism Open, 12, 100149, 2021. DOI: https://doi.org/10.1016/j.metop.2021.100149
Abstracts / Presentations:
The Endocrine Society’s 103rd Annual Meeting & Expo (ENDO Online 2021), Abstract #7284, March 20-23, 2021
American College of Cardiology Annual Meeting, Abstract 21-A-181050-ACC, Atlanta, GA, May 15-17 2021
American Association of Clinical Endocrinology Annual Meeting 2021, Abstract 1041569, May 26-29, 2021
81st Scientific Sessions of the American Diabetes Association, Abstract 631-P ePoster, June 25-29, 2021
Characterization of the cytokine secretion profile of breast cancer cells
7th Edition Breast Cancer Webinar, July 14-15, 2021; https://cancer.endeavorresearchgroup.com/
The Endocrine Society’s 103rd Annual Meeting & Expo (ENDO Online 2021), Abstract #4296. March 20-23, 2021
Journal of the Endocrine Society, Volume 5, Issue Supplement_1, April-May 2021, Page A385, https://doi.org/10.1210/jendso/bvab048.785.
ACTIVE RESEARCH PROJECTS
- Thyroid Neoplasia in LatinX patients (Principal Investigators: Emilia P. Liao, MD; Jose G. Sanchez Escobar, MD; Daniel Kuriloff, MD)
Description: The project investigates the clinical impact of diagnosing a thyroid neoplasm in LatinXpatients and examines novel, nonsurgical strategies to reduce the impact of overdiagnosing thyroid neoplasms in this under-represented minority population through registry design & maintenance & clinical procedures.
- Shire – Paradighm (Physicians Advancing Disease Knowledge in Hypoparathyroidism): A Registry for Subjects with Chronic Hypoparathyroidism (Principal Investigator: Natalie E. Cusano, MD)
Description: The objectives of this registry are to characterize and describe the clinical course of chronic hypoparathyroidism under conditions of routine clinical practice. This includes, but is not limited to, treatments, symptoms, health-related quality of life (HRQoL), clinical outcomes, and comorbidity. In addition, to characterize and describe the long-term efficacy and safety profile of rhPTH (1-84) treatment in patients with chronic hypoparathyroidism under conditions of routine clinical practice. This includes, but is not limited to, long-term effects of rhPTH (1-84) on renal, eye, bone, cardiovascular, and other outcomes relevant for patients with hypoparathyroidism.
- The role of irisin and other cytokines in ovarian physiology (Principal Investigators: Dimitar Avtanski, PhD; Leonid Poretsky, MD)
Description: The purpose of this project is to explore how chronic inflammation modulates the success of infertility treatment in women undergoing in vitro fertilization (IVF) procedure. For this project, we aim to obtain clinical data and follicular fluid samples from women undergoing IVF procedures. The ovarian follicular fluid samples will be used to purify granulosa cells for in vitro experiments. The remaining fluid will be used for hormone measurements. Our primary objective for this project is to establish molecular mechanism(s) by which irisin and other cytokines modulate ovarian steroid hormone production and thus may affect the outcomes of the IVF procedures.
- Investigation of the molecular mechanisms by which hypoxia modulates cytokine secretion in breast cancer cells (Principal Investigator: Dimitar Avtanski, PhD)
Description: The purpose of this project is to investigate the effect of CoCl2-induced hypoxia on cytokine gene and protein expression, to establish major signaling pathways involved in the hypoxia-induced effect on cytokine production in breast cancer cells, to investigate the effect of HIF-1α inhibition on breast cancer cytokine production, to investigate the association of tumor HIF-1α expression with tumor cytokine levels
- Role of resistin in mediating obesity-induced breast cancer progression (Principal Investigator: Dimitar Avtanski, PhD)
Description: In the context of cancer, epithelial to mesenchymal transition (EMT) induces the acquisition of cells with stem cell characteristics (cancer stem cells [CSCs]), which are believed to have the ability to initiate new tumors (tumor initiating cells [TICs]). Generally, TICs are characterized with high expression of cell surface protein CD44 and low or negative expression of CD24 (CD44+/CD24-/low). Resistin is an adipokine produced by the white adipose tissue (WAT) adipocytes and macrophages that plays a role in inflammation and insulin resistance. Circulating levels of resistin are increased in obesity. Preliminary reports suggest that resistin is associated with cancer progression and increases the metastatic potential of cancer cells. In this project we aim to investigate the effect of resistin on EMT and stem cell-like features in breast cancer cells, and the potential involvement of CAP1 in these processes. We hypothesize that resistin increases breast cancer aggressiveness by inducing EMT and appearance of stem-like features, and that this effect may depend on activation of CAP1
- A mixed-methods study to explore the social impact of first bone fracture on women with osteoporosis: Patient and caregiver perspectives (Principal Investigator: Tara Kim, MD)
Description: The major goal of this study is to determine the impact of fracture on social isolation
- Novo Nordisk – Long term comparative effectiveness of once weekly semaglutide versus standard of care in a real-world adult US population with type 2 diabetes – a randomized pragmatic clinical trial (Principal Investigator: Yael Harris, MD; Sub-Investigator: Leonid Poretsky, MD)
Description: The primary objective of this trial is to demonstrate superior long term effects of treatment with semaglutide compared to standard of care (SOC) when added to 1 or 2 oral antidiabetic medications on glycemic control and in need of treatment intensification in routine clinical practice in adult patients with T2DM
- Multidisciplinary registry research of transgender individuals (Principal Investigator: Natalie Cusano, MD)
Description: The project focuses on managing cardiovascular and bone density health in a cohort of transgender individuals as they age through prospective data collection and registry maintenance
- Multidisciplinary research study to examine cardiovascular and bone density health in transgender individuals (Principal Investigator: Natalie Cusano, MD)
Description: The project focuses on managing cardiovascular and bone density health in a cohort of transgender individuals as they age through routine blood tests, cardiovascular procedures and DXA scans over a two year period
- Effects of synthetic mono-carbonyl curcumin analogues on diabetes modulation of oxidative stress and inflammation (Principal Investigator: Dimitar Avtanski, PhD)
2020
ABSTRACTS:
American Diabetes Association (ADA) Abstracts:
80th Scientific Sessions of the American Diabetes Association, Abstract 2027-P, ePoster, June 12-16, 2020.
80th Scientific Sessions of the American Diabetes Association, Abstract 612-P, ePoster, June 12-16, 2020.
Endocrine Society Abstracts:
The Endocrine Society’s 102nd Annual Meeting & Expo (ENDO Online 2020), Abstract #6104, June 8-22, 2020. Journal of the Endocrine Society
Endo Society 2020 – Accepted Abstract. Supplemental April-May issue of the Journal of the Endocrine Society.
Optimization of experimental conditions for mimicking hypoxia in cultured breast cancer cells by using cobalt(II) chloride (CoCl2)
The Endocrine Society’s 102nd Annual Meeting & Expo (ENDO Online 2020), Abstract #6094, June 8-22, 2020.
An Indolent Recurrent Parathyroid Carcinoma – A Case Report
Poster presentation – Accepted for presentation for ENDO SOCIETY, March 2020.
New York Academy of Science:
Role of hypoxia in modulating cytokine secretion in breast cancer cells
NY Academy of Science Poster Webinar, “Cancer Metabolism and Signaling 2020,” April 17, 2020.
American Association of Clinical Endocrinologists (AACE):
A Functional Adrenocortical Oncocytoma – A Case Report
Presented at AACE, May 2020, Washington DC, USA.
ACTH Associated Hypercortisolism and Hypercoagulability – A Case Report
Presented at AACE, May 2020, Washington DC, USA.
Unilateral Adrenal Adenoma with bilateral adrenal hyperplasia
AACE 2020 – Accepted Abstract. AACE’s Journal, Endocrine Practice.
PUBLICATIONS:
Review Articles:
Polycystic ovary syndrome—Implications for gender identity
Yale Journal of Biology and Medicine 93(4): 529–537, 2020. PMCID: PMC7513432. PMID: 33005117
Peer reviewed articles:
Data Brief, 2020, 28:104798.
Metabolism Open 7, 2020.
The effects of a comprehensive multidisciplinary outpatient diabetes program on hospital readmission rates in patients with diabetes: A randomized controlled prospective study
Endocrine Practice. In press 2020.
PRESENTATIONS:
Polycystic Ovary Syndrome – Clinical Manifestations, Pathogenesis, and Implications for Gender Identity
Working Group on Gender, NYS Psychiatric Institute, and Department of Psychiatry, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, January 17, 2020.
Emerging Diabetes Technologies, National Conference
UBS Investment Bank, New York, NY, February 21, 2020.
First Annual Friedman Transgender Care Conference at Lenox Hill/Northwell Health
Lenox Hill Hospital, New York, NY, October 30, 2020.
OTHER PUBLICATIONS:
Medium, May 27, 2020.
2019
Original Reports:
Cytokine 120: 155-164, 2019.
NEJM, 381:520-530, 2019. DOI: 10.1056/ NEJMoa1900906.
Data in Brief 25:104112, 2019.
Data in Brief 25: 104118, 2019.
Animal Models and Experimental Medicine. Submitted, 2019.
J Clin Endocrinol Metab 2019 [Accepted].
J Clin Endocrinol Metab 2019;104:2748-2756.
Curr Opin Rheumatol 2019;31:381-387.
Mendeley Data, V1, DOI: 10.17632/tvt8zm37w5.2, http://dx.doi.org/10.17632/tvt8zm37w5.2, 2019.
Animal Model Exp Med. 2019; 00:1–7. https://doi.org/10.1002/ame2.12084.
Data in Brief, https://doi.org/10.1016/j.dib.2019.104798 Volume 28, February 2020.
Review Articles, Chapters:
In: “Transgender medicine – A multidisciplinary approach”, pp 377-462, L. Poretsky and W. Hembree editors, Springer, New York, 2019.
In: “Transgender medicine – A multidisciplinary approach”, pp 143-163, L. Poretsky and W. Hembree editors, Springer, New York, 2019.
Books:
Springer, New York, 2019.
Presentations at Regional and/or National Meetings:
Endocrine Society 101th Annual Meeting, Abstract #5553, New Orleans, LA, March 22-26, 2019.
Endocrine Society 101th Annual Meeting, Abstract #5562, New Orleans, LA, March 22-26, 2019.
Endocrine Society 101th Annual Meeting, Abstract #5781 , New Orleans, LA, March 22-26, 2019.
79th Annual Meeting of the American Diabetes Association, Abstract 2215-PUB, San Francisco, CA, June 7-11, 2019.
American Association for Cancer Research (AACR) Annual Meeting, March 29th-April 3rd, 2019, Atlanta, Georgia, USA, Abstract # 310/1.
Poster presented at 101st Endocrine Society Meeting, New Orleans, LA, March 23-26, 2019.
Changes in Cortical Porosity and Bone Strength Through Four Years of rhPTH(1-84) Therapy in Hypoparathyroidism
Accepted for Plenary Poster Presentation at the American Society of Bone and Mineral Research 2019 Annual Meeting, September 20-23, 2019, Orlando, Florida.
2018
Peer Review:
In: Molecular Medicine 24(1):29-45, 2018.
In: Endocrine Practice, DOI:10.4158/ACCR-2018-0086, 2018.
Obesity and breast cancer bone metastasis
In: [manuscript in preparation]
Role of microRNAs as regulatory link between obesity and breast cancer
In: [manuscript in preparation]
Book Chapter:
In: Liao E. (eds) Extraskeletal effects of vitamin D. Contemporary Endocrinology. Humana Press, Cham, Print ISBN 978-3-319-73741-6, Online ISBN 978-3-319-73742-3
Resources for transgender persons
In: “Transgender Medicine – Interdisciplinary Approach”. L. Poretsky, Ed. Submitted.
Endocrinology of transgender care—adults
In: “Transgender Medicine – Interdisciplinary Approach”. L. Poretsky, Ed. Submitted.
Abstracts:
Role of AXL receptor tyrosine kinase in mediating resistin effects on epithelial to mesenchymal transition (EMT) in breast cancer
In: The Feinstein Institute Summer Students Poster Presentation, Manhasset, New York
Role of adenylyl cyclase-associated protein 1 (CAP1) in mediating resistin actions in mouse liver cells
In: American Diabetes Association 78th Scientific Serrions, Orlando Florida – Abstract # 1754-P
Resistin increases breast cancer metastatic potential by inducing epithelial to mesenchymal transition and stemness
In: Northwell Health 2018 Academic Awards Day, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York – Abstract # BS4
Obesity as a multifactorial disease: Energy metabolism, insulin resistance, endoscopic bariatric intervention and the pathophysiology of small intestinal bacterial overgrowth (SIBO) in human obesity
In: 4th Annual Feinstein Institute Research Symposium: Diabetes, Endocrinology and Metabolic Disorders, April 10th, 2018, Manhasset, New York – Abstract # 6
The role of circulating advanced glycation end-products (AGEs) in predicting clinically significant coronary artery disease
In: 4th Annual Feinstein Institute Research Symposium: Diabetes, Endocrinology and Metabolic Disorders, April 10th, 2018, Manhasset, New York – Abstract # 3
Role of adenylyl cyclase-associated protein 1 (CAP1) in mediating resistin actions in mouse liver cells
In: 4th Annual Feinstein Institute Research Symposium: Diabetes, Endocrinology and Metabolic Disorders, April 10th, 2018, Manhasset, New York – Abstract # 2
Resistin inhibits insulin signaling in adenylyl cyclase-associated protein 1 (CAP1)-dependent manner
In: 4th Annual Feinstein Institute Research Symposium: Diabetes, Endocrinology and Metabolic Disorders, April 10th, 2018, Manhasset, New York – Abstract # 1
Resistin inhibits insulin signaling in adenylyl cyclase-associated protein 1 (CAP1)-dependent manner
In: The Endocrine Society’s 100th Annual Meeting & Expo, Chicago, Illinois – Abstract # SUN-141
Resistin increases breast cancer cell motility and induces cellular mesenchymal reprogramming
In: The Endocrine Society’s 100th Annual Meeting & Expo, Chicago, Illinois – Abstract # SAT-329 – abstract selected for inclusion in a moderated poster session
2017
In: Principles of Diabetes Mellitus, pp 43-55, 3rd edition, L. Poretsky, Ed. Springer, New York, 2017.
KEYWORDS: Islets; beta cell; insulin; alpha cell; glucagon; amylin; ghrelin
Clin Obstet Gynecol Reprod Med, 3(5):1-4, 2017.
KEYWORDS: IGF-I; IGFBP-1; FGF21; GDM
In: Principles of Diabetes Mellitus, pp 3-19, 3rd edition, L. Poretsky, Ed. Springer, New York, 2017.
In: Principles of Diabetes Mellitus pp 659-677, 3rd edition, L. Poretsky, Ed. Springer, New York, 2017.
KEYWORDS: Polycystic Ovary Syndrome; Insulin Resistance; Oligomenorrhea; Hirsutism; Androgens
J Diabetes Complications 31 (12), 1681-1685, 2017.
KEYWORDS: Diabetes mellitus; Length of stay; Primary diagnosis of diabetes; Readmission rates; Rehospitalization
Reprod Biol, 17(3):285-288, 2017.
KEYWORDS: Irisin; Ovary; Pituitary
Book
2016
Horm Metab Res. 2016 Feb 5. [Epub ahead of print] PMID: 26849824.
KEYWORDS: PPARγ – β-catenin – BSP – OPG – FGF23 – calcium – phosphate
Horm Mol Biol Clin Invest, 25(1):15-28, 2016 PMID: 26943610
2015
Clinical Journal Am Society Nephrology, 10 (5): 59-66, 2015.
KEYWORDS: advanced glycation end product; albuminuria; diabetic nephropathy; ethnicity; oxidative stress
2014
Endocrinology and Metabolism Clinics of North America, 43:1, xvii-xviii, 2014
ErbB Receptor-Driven Prolactinomas Respond to Targeted Lapatinib Treatment in Female Transgenic Mice
Endocrinology and Metabolism Clinics of North America, 43:1, xvii-xviii, 2014
Endocrinology and Metabolism Clinics of North America, 43:1, xvii-xviii, 2014
KEYWORDS: Insulin resistance; Long-term effects; Polycystic ovary syndrome; Risk factors
J Diabetes 6:360-368, 2014 © 2013 The Authors
KEYWORDS: Chinese pregnant women; HMW-adiponectin; T-adiponectin; gestational diabetes; glucose intolerance; inflammatory markers; 华裔妊娠妇女,妊娠糖尿病,葡萄糖耐量,HMW-脂联素,炎症标志物,T-脂联素
2013
Endocrinology and Metabolism Clinics of North America, 42:915-946, 2013 © 2013 Elsevier Inc
KEYWORDS: Diabetes in pregnancy, Insulin and the ovary, PCOS
J Bone Miner Res. 2013 Aug;28(8):1778-83 © 2013 American Society for Bone and Mineral Research
KEYWORDS: Diabetes, advanced glycation end products (AGE), retinopathy, neuropathy, nephropathy, diabetes complications, receptor for AGE (RAGE), methylglyoxal
Journal of American Physicians and Surgeons, 18(2), 2:50-54, 2013
Horm Metab Res 2013; 45: 1-8 © 2012 Georg Thieme Verlag KG
KEYWORDS: osteoblast, oral antidiabetic drugs, bone homeostasis
Endocrinology and Metabolism Clinics of North America, 42:657-1014, 2013 © 2013 Elsevier Inc
KEYWORDS: Complications, Pathogenesis, Diabetes
2012
PNAS September 25, 2012, vol. 109, no. 39, 15537–15538 © 2012 National Academy of Sciences
2011
Endocrinol Metab Clin N Am 40 (2011) 865–894 © 2011 Elsevier Inc.
KEYWORDS: Polycystic ovary syndrome (PCOS), Infertility, Pregnancy
J. Endocrinol. Invest. 34: 770-774, 2011 © 2011, Editrice Kurtis
KEYWORDS: CABG, continuous insulin infusion, diabetes mellitus, insulin
Horm Metab Res 2011:43: 386 – 390 © Georg Thieme Verlag KG
KEYWORDS: insulin, IGF-1, steroid hormones, mitogen activated protein kinase, progesterone synthesis, polycystic ovary syndrome
In: “Type 1 Diabetes/Book 3”, CP Liu, Ed., InTech Open Access Publisher, Rijeka, Croatia, 2011.
PPAR Research Volume 2011, Article ID 926438, 5 pages © 2011 Takako Araki et al
Horm Metab Res 2011: 43: 250 – 256 © Georg Thieme Verlag KG
KEYWORDS: thiazolidinediones, estrogens, aromatase, insulin sensitivity, PPAR- γ, polycystic ovary syndrome
2010
Principles of Diabetes Mellitus, pages 37-55 © Springer Science+Business Media, LLC 2010
Journal of Diabetes 2 (2010) 36-40 © 2010 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Principles of Diabetes Mellitus, pages 3-16 © Springer Science+Business Media, LLC 2010
Principles of Diabetes Mellitus, pages 515-530 © Springer Science+Business Media, LLC 2010
© Springer Science+Business Media, LLC 2010
Horm Metab Res 2010; 42: 754–757
2009
Horm Metab Res 2009; 41: 244 – 249 © Georg Thieme Verlag KG
KEYWORDS: endocrine effects, DHEA, HIV infection, premenopausal women, insulin sensitivity
Diabetes Metab Res Rev 2009; 25: 417–419 2009 © John Wiley & Sons, Ltd.
KEYWORDS: vitamin D; type 1 diabetes mellitus; type 2 diabetes mellitus; adult onset latent autoimmune diabetes (LADA)
2008
Otolaryngology–Head and Neck Surgery (2008) 138, 403-404 © 2008 American Academy of Otolaryngology–Head and Neck Surgery Foundation
2007
Insulin Volume 2, Number 3:144-145 2007 Elsevier Inc.
The Journal of Clinical Endocrinology & Metabolism 92(6):2232–2239, © 2007 by The Endocrine Society